An Introduction

We come from all over the world to study interesting scientific questions. The Raskatov lab pursues two independent research interest themes that may be broadly defined as (i) biomedical and (ii) materials research.

(i) We use a cross-disciplinary chemical neuroscience approach that combines experiment with theory to rationally design novel approaches to block toxicity of Amyloid Beta to develop Alzheimer’s Disease therapeutics. We are also becoming increasingly interested in methionine oxidation and the aging brain.

(ii) In developing Amyloid Beta Chiral Inactivation we became interested in the “rippled sheet”, a structural motif hypothesized by Linus Pauling and Robert Corey in 1953. In 2022, almost 70 years later, our lab published the first crystallographic study of rippled sheets. We are now using our insights to devise supramolecular rippled sheet polymers as a new class of peptidic materials with unique properties.